POLYMORPHISMS OF HPC2/ELAC2 AND SRD5A2
(5α-Reductase Type II) GENES IN PROSTATE CANCER İzmirli M1,*, Arikan B2, Bayazit Y3, Alptekin D4 *Corresponding Author: Muzeyyen İzmirli, Department of Medical Biology, Faculty of Medicine, Bezmialem
Vakif University, 34093, Istanbul, Turkey; Tel.: +90-212-523-37-19, Fax: +90-212-523-23-26;
E-mail: muzeyyenizmirli@gmail.com. page: 31 download article in pdf format
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Abstract
Prostate cancer is the proliferation of malignant
cells in the prostate gland. The HPC2/ELAC2 gene on
chromosome 17p11.2 and SRD5A2 gene on chromosome
2p22-23 are predisposing genetic factors. We
examined the relationship between Ser217Leu and
Ala541Thr polymorphisms of the former gene, and
Ala49Thr and Val89Leu polymorphisms of the latter
gene to prostate cancer in Turkish men, using the polymerase
chain reaction (PCR) method and appropriate
restriction enzymes. The HPC2/ ELAC2 gene Ser217-
Leu and SRD5A2 gene Ala49Thr polymorphisms were
associated with an increased risk of prostate cancer in
Turkish men [for the HPC2/ELAC2 gene Ser217Leu
polymorphism: odds ratio (OR) 2.7; confidence interval
95% (CI 95%) 1.6-4.8; p 0.000<0.05, and for the
SRD5A2 gene Ala49Thr polymorphism: OR 2.4; CI
95% 1.2-4.9; p 0.004<0.05].
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