The digenesis of gonads is a rare enough genetic pathology, revealing at 1 on 10-12 thousand live-born children. The principles of treatment of the given pathology are known rather for a long time, but there is no precise circuit substitutive hormonal of therapy at the various forms the digenesis of gonads.

Goal. To value the efficiency of Femoston by the digenesis of gonads.

Materials and methods. We examined 50 female patients in age of 12 – 23 with various forms of digenesis of gonads. We made the complex clinical and laboratory investigation.

Results and conclusions. On cariotype we determined that Swyer’s syndrome – 5 (10 %) – 46,XY; mixed form (45,XO/46,XY) – 1 (2 %), typical form or Shereshevsky-Turner’s syndrome (45,XO) – 7 (14 %), mosaic form (45,XO/46,XX) – 7 (14 %), pure form (46,XX) – 30 (60 %).

Comparison of hormonal parameters of the patients with the digenesis of gonads after traditional cyclic and modified hormonotherapy

Summing up discussion of various kinds of hormonotherapy, it is necessary to emphasize the expressed advantages of purpose patients with the various forms of digenesis of gonads of preparations containing natural female sexual hormones 17? - estradiol as a preparation Femoston. 

Groups	A kind of medical influence	FSH	LH	Estradiol	Progesterone
		mME/ml		pmol/l	nmol/l
I n = 17	Starting Ethinyl estradiol	58,1 ± 4,3 25,8 ± 2,61	29,82±5,69 12,2 ± 1,25	156,3 ± 9,8 175,3±10,0	1,6 ± 0,12 2,62 ± 0,46
II n = 10	Regulon	70,8 ± 3,5 14,8 ± 2,0	14,3 ± 0,32 8,8 ± 1,13	144,8 ± 12,0 194,9 ± 13,0	1,75 ± 0,15 3,02 ± 0,68
III n = 23	Femoston	108 ± 10,5 15,9 ± 1,8	11,2 ± 0,25 9,3 ±  0,95	165 ± 12,8 265,3±14,6	2,0 ± 0,22 3,1 ± 0,68