PP106. ASSOCIATION OF CYTOKINE GENES POLYMORPHISMS WITH ESSENTIAL HYPERTENSION IN TATARS FROM RUSSIA
Y.R. TIMASHEVA1, T.R. Nasibullin1, A.N. Zakirova2, O.E. Mustafina1
1. Institute of Biochemistry and Genetics of Ufa Scientific Centre of Russian Academy of Science 2. Bashkir State Medical University
e-mail: ianina_t@yahoo.com
*Corresponding Author:
page: 95
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Abstract
Extensive searches have been performed to determine candidate genes for essential hypertension (EH). It has been shown that patients with EH had an altered profile of pro- and anti-inflammatory cytokines. The aim of the present study was to determine an association of interleukin-6, interleukin-12 and interleukin-10 gene polymorphism with EH in Tatars from Bashkortostan, Russia. The study comprised 355 hypertensive patients and 173 unrelated healthy subjects from Tatar ethnic group (Bashkortostan, Russia). DNA isolated from whole venous blood using phenol-chloroform extraction was amplified in polymerase chain reaction. IL-6 -572 G/C, IL-12 1159 C/A and IL-10 -627 C/A genotypes were resolved by electrophoresis in agarose gel after digestion by restriction enzymes. We have found that IL-10 -627 *C/*C genotype and *C allele were associated with decreased risk of EH (OR=0.45, P=0.005, CI: 0.26-0.78 and OR=0.47, P=0.002, CI: 0.29-0.75, respectively). IL-6 genotypes and allele distribution did not significantly differ in patients and control group, but IL-6 -572 *G/*G genotype frequency was found to be significantly higher among those patients who had stroke, comparing to hypertensive patients without complications of EH (P=0.036) and with normotensive control subjects (P=0.028). Carriers of IL-12 1159 *A/*A genotype had lower risk of EH (OR=0.51, P=0.006, CI: 0.32-0.82) Our results suggest a role for cytokine genes in the pathogenesis of cardiovascular disease.
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