PP101. GENETIC POLYMORPHISM OF GLUTATHIONE-S-TRANSFERASE T1 AND M1 IN THE NEWBORNS WITH INFANT RESPIRATORY DISTRESS SYNDROME (IRDS) IN UKRAINIAN POPULATION
N. G. Gorovenko, Z.I. Rossokha, S.V.Podolskaya
Department of Medical Genetics, National Medical Academy for Postgraduate Education named after P.L. Shupyk
e-mail: rossokhazoya@mail.ru
*Corresponding Author:
page: 93
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Abstract
Text: Infant respiratory distress syndrome (IRDS) affects 10 % of all premature infants and rarely full-term newborns. Risk factors are prematurity and oxidative stress during delivery for newborns at birth. Air breathing exposes the lung to reactive oxygen species (ROS). Antioxidant enzymes may protect the lung from ROS-mediated injury. The glutathione S-transferases (GSTs) are a multi-gene family of enzymes involved in the detoxification, and, in a few instances, activation of a wide variety chemicals. Members of the GST family are involved in the metabolism of reactive oxygen species. We conducted a case-control study of 72 cases of IRDS (22 full-term newborns and 50 premature newborns) and 70 control group (clinical healthy full-term newborns). Genetic polymorphism of GSTT1 and GSTM1 were detected by multiplex polymerase chain reaction (PCR). Results: In our investigation we observed an increased frequency of GSTT1 null genotypes among newborns with IRDS (34,72%) compared to newborns in the control group (12,86%). Among newborns with IRDS a statistically significant increase in the frequency of the GSTT1 null-genotype was observed, χ2 =8.16, P<0.01 (OR=3.6052 (CI 95%: 1.5385-8.4484). There were no significant differences between the polymorphism of GSTM1 genotypes in infants with IRDS and control group . Our investigations have shown associations between GSTT1 null-genotype of newborns and increased risk of IRDS. Genetic factors play an important role in the onset of IRDS.
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