PP56. BCR/ABL FUSION IN A CHILD WITH CHRONIC MYELOIC LEUCAEMIA
Z. GUCEV1, S. Koceva1, O. Muratovska1, S. Glamocanin1, Gj. Jovanov2, V. Vankovska1, L. Tasevska1, B Taseva1, A. Jancevska1
1. Pediatric Clinic, Medical faculty, Skopje, 2. Health Station Skopje, R. Macedonia
e-mail: gucevz@gmail.com
*Corresponding Author:
page: 73
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Abstract
Head to tail fusion of ABL protooncogene from chromosome 9 to breakpoint cluster region (BCR) on chromosome 22 generates a hybrid BCR/ABL gene. This hybrid is found in adult and in childhood myelogenous leucemia. In addition, the same fusion is found in 2-10% od childhood lymphoblastic leucemias. Since this BCR/ABL fusion is an ominous prognostic factor (confering drug resistence) its early determination is important for the choice of the intensity of the treatment protocol. We analyzed 52 children with leucaemias for the BCR/ABL fusion. RNA was isolated and RT-PCR was performed with specific primers. Among 42 children with acute lymphoblastic leucaemias and 6 children with acute myeloic leucemia no BCR/ABL fusion was found. One out of four children with chronic myelogenous lekemia was BCR/ABL positive (25%). Hyperleucocitosis and skin haemathomas were initial signs. Cytological and cytochemical analysis confirmed a chronic myelogenous leuc aemia. A chemotherapy was started and bone marrow transplantation was performed. Further monitoring of the patient for BCR-ABL fusion is in progress.
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