In this study; it is aimed to compare of signals with FISH methods between 12p and 15q telomere which are hypertensive persons and normotensive persons. We accepted that the persons who are sistolic blood pressure >140mmHg and diastolic blood pressure >90mmHg, are essential hypertension. These persons have not any cronic illnesses. Age range of  hypertensive and normotensive persons is determined as 45-89. We prepared that metaphases preparates which are based on peripheral blood sample from hypertensive 5 persons and normotensive 5 persons, and we made fluorescence in situ hybridization (FISH) application by using 12p ve 15q  CYTOCELL Telomer Probs. We have completed at study-groups which are applied 12p and 15q telomere probs by FISH methods on hypertensive and normotensive groups. There is no difference between signals of hypertensive and signals of normotensive groups.